Trelew, Argentina

At over 100,000 people, Trelew is the largest city in the Chubut region of Patagonia, but it's no bustling metropolis. The wool industry dominates the local economy, with 90% of Argentina's wool processing happening here. While the city has some cultural attractions like a paleontology museum, the climate is cold and dry, and the bureaucracy can be a persistent headache. Trelew is probably best suited for those seeking a quieter, more industrial pace of life in Patagonia.