Qarasu, China

Living in this remote border town is a trial for the faint of heart. Qarasu, China has a population of just 71,446, and serves as the starting point for the 995-kilometer Asian Highway 66 that winds through rugged mountain terrain into Tajikistan. The bureaucratic hassles of crossing this border are a persistent headache.

Those seeking a quiet, secluded life far from the noise of China's megacities may find Qarasu appealing. But the isolation, harsh climate, and logistical challenges of living on the periphery make it a poor choice for most. This town is best suited for intrepid adventurers, not the average expat.