Tefé, Brazil

With a population of just 53,970, Tefé is a small and isolated outpost in the heart of the Amazon. Getting there is no easy feat, with no roads and access limited to river boats or flights from the distant city of Manaus. The only major commercial hub in the middle Solimões region, the city serves as a launching point for trips to the Mamirauá Reserve, but those seeking an urban lifestyle will find the lack of infrastructure and heavy bureaucracy to be a persistent headache. The climate is typical of the Amazon, hot and humid year-round. Ultimately, Tefé is best suited for adventure-seeking naturalists and those looking to immerse themselves in the remote wilderness of the world's largest rainforest.