Presidente Prudente, Brazil

This sleepy interior city has a lot going on beneath the surface. With a population of 165,484, Presidente Prudente boasts a robust economy driven by services and industry. However, the heavy bureaucracy and significant crime rates in this region are persistent headaches for residents. While the city has high-quality universities and a thriving innovation ecosystem, those seeking a laidback, trouble-free lifestyle may want to look elsewhere.