Ouro Preto do Oeste, Brazil

With a population of just 83,857, Ouro Preto do Oeste is a sleepy outpost in the Amazon basin that offers little to attract expats or young professionals. The city's remote location and massive 1,970 km2 area make it a logistical nightmare to navigate. Bureaucracy is a persistent headache, as is the oppressive tropical climate. This is a place for the hardy, self-sufficient types who crave isolation over amenities or entertainment.