Guajará Mirim, Brazil

Living in Guajará Mirim means navigating a municipality of just 32,583 people, dwarfed by the vast 24,856 square kilometers it sprawls across. The city's remote location along the Mamoré River, right on the Bolivian border, means dealing with a persistent bureaucratic headache - Bolivia has a consulate here, while Brazil's is on the other side. On the plus side, the area boasts a wealth of protected nature reserves, including the 22,540-hectare Traçadal Biological Reserve. But for most, the isolation and administrative hassles of this sleepy outpost will prove too much - Guajará Mirim is best suited for those seeking a true off-the-grid experience.