Boca do Acre, Brazil

With a population of just 25,005, Boca do Acre is a remote outpost in the heart of the Amazon. The city holds a massive 92% share of the 311,000-hectare Mapiá-Inauini National Forest, as well as the 133,637-hectare Arapixi Extractive Reserve. While the natural wonders on its doorstep are undeniable, the bureaucracy and red tape involved in accessing these protected lands is a persistent headache. For those seeking a true off-the-grid experience surrounded by untamed wilderness, Boca do Acre may be an enticing, if challenging, destination.