Sipe Sipe, Bolivia

Forget the quaint colonial charm - living in this sleepy Bolivian town of 47,000 people comes with its fair share of headaches. The bureaucratic red tape is a persistent issue, as evidenced by the population growth crawling from 19,132 in 1992 to just 41,571 as of 2012. And while the Battle of Sipe-Sipe may have been a decisive historical moment, today's residents face a far more mundane struggle against the area's remote location and limited infrastructure. Only the most resilient and adaptable expats are likely to thrive in this provincial outpost.